Dr. Raina's SAFE HANDS, is a complete home for sexual dysfunction treatment, he is among best sexologist in Delhi and you can get best sexologist treatment in Delhi NCR & India
Showing posts with label Premature Ejaculation solution. Show all posts
Showing posts with label Premature Ejaculation solution. Show all posts
Premature
ejaculation is a common problem, which is found in 30% to 40% of men. This is
when semen is ejaculated during intercourse before your partner wants it. It
often occurs before or immediately after penetration into the vagina during
intercourse. Premature ejaculation can be a frustrating experience for both you
and your sexual partner.Although the good news is that there is a
cure for this problem. The complete treatment of premature ejaculation is
available at Safe Hands Multispecialty STD Clinic in Delhi.Here the best sexologist Dr. Vinod Raina,
who has lived in former CMO Safdarjung Hospital, has an experience of 21 years.
How common is premature
ejaculation?
Premature
ejaculation is the most common type of sexual dysfunction in men. In India,
about one in five men between the ages of 8 and 59 suffers from premature
ejaculation.30% to
40% of men suffer premature ejaculation at some point in their lives.
Which time frame medically
defines male ejaculation as premature ejaculation?
The Indian Psychiatric
Association defines three levels of severity (mild, moderate, severe) based on
the timing of ejaculation, with mild being less than a minute.So many doctors would define premature
ejaculation as ejaculation within a minute of starting intercourse.
Regardless of professional opinion, your feelings about what is premature are
also considered.
Are there other symptoms of
premature ejaculation?
No. The only
symptom of premature ejaculation is the condition itself.
What causes premature
ejaculation?
Physical,
chemical and emotional/psychological factors cause premature ejaculation.
A hormonal
problem with oxytocin levels, which have a role in sex function in men. Other
hormone levels that play a role in sexual function include luteinizing hormone
(LH), prolactin, and thyroid stimulating hormone (TSH).
Low levels of
serotonin or dopamine, chemicals in the brain that are involved in sexual
desire and arousal.
Way to Connect Dr. Vinod Raina
You Can Call on
His Mobile No. 7687878787,
9871605858 & also Connect
from Whatsapp
Address – E 34
Ekta Apartment Saket Near Malviya Nagar Metro Station Gate No . 4
Premature ejaculation (PE) is a prevalent sexual condition
among men. According to recent normative statistics, males with an intravaginal
ejaculatory latency time (IELT) of less than one minute have
"definite" PE, whereas men with IELTs between one and 1.5 minutes
have "probable" PE. Although there is inadequate empirical data to
determine the etiology of PE, there is some indication that males with PE have
high levels of sexual anxiety and inherited impaired sensitivity of central
5-HT (5-hydroxytryptamine, serotonin) receptors. Pharmacological modulation of
the ejaculatory threshold with off-label daily or on-demand selective serotonin
re-uptake inhibitors is well tolerated and provides patients with a high
likelihood of achieving improved ejaculatory control within a few days of
starting treatment, as well as improvements in sexual desire and other sexual
functions. Dapoxetine, a Premature
ejaculation-selective serotonin
transport inhibitor, represents a significant advancement in sexual medicine.
These medications provide patients with the convenience of on-demand dosage,
considerable improvements in IELT, ejaculatory control, and sexual satisfaction;
all while causing minimal side effects.|Premature
Ejaculation Treatment
PHYSIOLOGY OF EJACULATION
Ejaculation is a reflex involving sensory receptors and
areas, afferent routes, brain sensory areas, cerebral motor centers, spinal
motor centers, and efferent pathways. Normal ante grade ejaculation involves
three essential mechanisms: emission, ejection, and orgasm. Emission is the
outcome of a sympathetic spinal cord reaction triggered by genital and/or
cerebral erotic impulses, and it involves the contraction of accessory sexual
organs sequentially. The degree of voluntary emission control gradually lowers
until ejaculatory inevitability is reached. Ejection is also accompanied by a
sympathetic spinal cord response over which the patient has little or no
deliberate control. Closure of the bladder neck, rhythmic contractions of the bulb
cavernous, bulbospongiosus, and other pelvic floor muscles, and relaxation of
the external urinary sphincter are all required for ejection. Orgasm is the
product of pudenda cerebral processing.
The ejaculatory reflex is primarily controlled by a complex
interplay between central serotonergic and dopaminergic neurons, with
cholinergic, adrenergic, nitrergic, oxytocinergic, galanergic, and GABAergic
neurons also playing a role. The brain events that occur during ejaculation, as
well as the abnormalities evident in men with PE, have not been well described
using positron emission tomography (PET) and functional magnetic resonance
imaging (FMRI). Several forebrain regions, notably the medial peptic area
(MPOA) and the nucleus paragigantocellularis (nPGi), integrate seminal emission
and ejection into the complicated pattern of copulatory behavior. Ejaculation
is topically inhibited via descending serotonergic pathways from the nPGI to
the lumbosacral motor nuclei. [3 The MPOA enhances ejaculation by inhibiting
the nPGI. In male rats, a population of lumbar spin thalamic neurons (LSt
cells) has been found.
PE DRUG TRIAL DESIGN
The results of PE drug clinical trials are only reliable,
interpretable and capable of being generalized to patients with the disorder
studied when conducted in well defined and consistent populations,
differentiation of lifelong and acquired PE as separate PE subgroups, exclusion
or treatment as a separate subgroup subjects with erectile dysfunction (ED) or
other co-morbid sexual disorders, using a double-blind placebo controlled study
design, and consistent objective physiological measures or sensitive, validated
outcome assessment instruments as study endpoints. In PE studies, the study
population should be well characterized, representative of the overall patient
population and defined using a multivariate definition of PE. As the population
of men with PE is not homogenous, lifelong and acquired PE should be treated as
demographically and etiologically distinct disorders and analyses as separate
PE subgroups. Subjects should be involved in a stable, monogamous heterosexual
relationship, prepared to attempt intercourse on a regular basis and provide
written informed consent. The presence of co morbid ED should be evaluated
using a validated instrument such as the International Index of Erectile
Function (IIEF) and patients with any degree of ED should be either excluded
from the study or treated as a separate subgroup. Patients with hypoactive
sexual desire or other sexual disorders, urogenital infection, major
psychiatric disorders, a history of drug and alcohol abuse or contraindications
to the study drug should be excluded from the study. Measurement of the
intravaginal ejaculatory latency time (IELT) by stopwatch is the best method to
diagnose PE and the response to treatment and should be used as a primary
efficacy endpoint. Laboratory studies of ejaculatory dysfunction may be
simplified by the use of the Sexual Assessment Monitor (SAM), an electronic
data collector which comprises a vibrator to induce ejaculation and a sensor to
measure time-to-erection and IELT by the detection of ejaculatory pulses, but
the role of such devices in large at-home Phase III clinical trials is limited.
Recent normative IELT data supports earlier suggestions by several authors that
intravaginal ejaculatory latency times (IELTs) of less than 1 minute or less
than 2 minutes be regarded as cut-points for inclusion in a clinical trial.
Subjective patient reported outcomes (PROs) of ejaculatory control, sexual
satisfaction and bother/distress are important additional efficacy endpoints
and can be evaluated using validated patient reported outcome instruments.
Research into the development of validated, reliable and consistent patient reported
outcome measures is ongoing.
TREATMENT :-
Best Premature Ejaculation Treatment in Delhi is
performed by Dr. Vinod Raina
If You Have a Premature Ejaculation, Visit Dr.
Raina's SAFE HANDS (Call: 7687878787)
How To Reach Dr Vinod Raina
To reach Dr. Vinod Raina, you can contact him on WhatsApp
on his number 9871605858. You can also contact him on our official website:
KEYWORD - Premature Ejaculation treatment in
Delhi, Premature Ejaculation Treatment, Premature Ejaculation solution, Best
treatment for Premature Ejaculation, Early Discharge Treatment in Delhi
.jpg)